Axcaliber: A method for measuring axon diameter distribution from diffusion MRI

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AxCaliber: a method for measuring axon diameter distribution from diffusion MRI.

The diameter of a myelinated nerve axon is directly proportional to its conduction velocity, so the axon diameter distribution helps determine the channel capacity of nervous transmission along fascicles in the central (CNS) and peripheral nervous systems (PNS). Previously, this histological information could only be obtained using invasive tissue biopsies. Here we propose a new NMR-based appro...

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AxCaliber – A Method to Measure the Axon Diameter Distribution and Density in Neuronal Tissues

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AxCaliber: An MRI Method to Measure the Diameter Distribution and Density of Axons in Neuronal Tissue

and Density of Axons in Neuronal Tissue P.J. Basser, T. Blumenfeld , G. Levin, Y. Yovel, Y. Assaf, STBB/LIMB/NICHD, NIH; Department of Neurobiochemistry, Tel Aviv University Discussion The experimental determination of the diameter distribution, p(d), of emulsions and droplets has long been studied using NMR methods (see (1,2)). In these experiments, p(d) is estimated from PFG data by assuming ...

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Optimal diffusion-gradient waveforms for measuring axon diameter

Introduction: Measuring microstructure parameters of brain tissue, such as axon radius, in vivo is a challenge in diffusion MRI. Current approaches typically use pulsed-gradient spin-echo (PGSE) [1] or stimulated-echo (STEAM) [2] sequences, both of which use a rectangular diffusion-gradient pulse. However other shapes of diffusion-gradient pulses such as oscillating [3] or chirped [4] may provi...

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Efficient Axon Diameter Distribution Recovery with Long Diffusion Time

PURPOSE: This work proposes an original method to recover axon diameter distributions (ADD) of white matter (WM) using nuclear magnetic resonance. The technique might be interpreted as an interesting simplification of the AxCaliber framework [1], which leads to a simpler model and an extremely faster acquisition protocol. To test and validate our method, we use the open-source toolkit CAMINO [2...

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ژورنال

عنوان ژورنال: Magnetic Resonance in Medicine

سال: 2008

ISSN: 0740-3194,1522-2594

DOI: 10.1002/mrm.21577