Axcaliber: A method for measuring axon diameter distribution from diffusion MRI
نویسندگان
چکیده
منابع مشابه
AxCaliber: a method for measuring axon diameter distribution from diffusion MRI.
The diameter of a myelinated nerve axon is directly proportional to its conduction velocity, so the axon diameter distribution helps determine the channel capacity of nervous transmission along fascicles in the central (CNS) and peripheral nervous systems (PNS). Previously, this histological information could only be obtained using invasive tissue biopsies. Here we propose a new NMR-based appro...
متن کاملAxCaliber – A Method to Measure the Axon Diameter Distribution and Density in Neuronal Tissues
Y. Assaf, T. Blumenfeld, G. Levin, Y. Yovel, P. J. Basser Department of Neurobiochemistry, Tel Aviv University, Tel Aviv, Israel, Functional Brain Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, NICHD, National Institutes of Health, Bethesda, MD, United States Introduction Myeloarchitecture refers to different histological features, e.g., axonal density, myelin basic protein conten...
متن کاملAxCaliber: An MRI Method to Measure the Diameter Distribution and Density of Axons in Neuronal Tissue
and Density of Axons in Neuronal Tissue P.J. Basser, T. Blumenfeld , G. Levin, Y. Yovel, Y. Assaf, STBB/LIMB/NICHD, NIH; Department of Neurobiochemistry, Tel Aviv University Discussion The experimental determination of the diameter distribution, p(d), of emulsions and droplets has long been studied using NMR methods (see (1,2)). In these experiments, p(d) is estimated from PFG data by assuming ...
متن کاملOptimal diffusion-gradient waveforms for measuring axon diameter
Introduction: Measuring microstructure parameters of brain tissue, such as axon radius, in vivo is a challenge in diffusion MRI. Current approaches typically use pulsed-gradient spin-echo (PGSE) [1] or stimulated-echo (STEAM) [2] sequences, both of which use a rectangular diffusion-gradient pulse. However other shapes of diffusion-gradient pulses such as oscillating [3] or chirped [4] may provi...
متن کاملEfficient Axon Diameter Distribution Recovery with Long Diffusion Time
PURPOSE: This work proposes an original method to recover axon diameter distributions (ADD) of white matter (WM) using nuclear magnetic resonance. The technique might be interpreted as an interesting simplification of the AxCaliber framework [1], which leads to a simpler model and an extremely faster acquisition protocol. To test and validate our method, we use the open-source toolkit CAMINO [2...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2008
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.21577